Thursday, December 7, 2017
4:00 pm
Spalding Laboratory 106 (Hartley Memorial Seminar Room)

Chemical Engineering Seminar

Engineering Next-Generation T Cells for Cancer Immunotherapy
Yvonne Chen, Assistant Professor, Department of Chemical and Biomolecular Engineering, University of California, Los Angeles

The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. This presentation will highlight the the potential of synthetic biology in generating novel mammalian cell system with multifunctional outputs for therapeutic applications.

Contact Allison Ouellette allison@cheme.caltech.edu at (626) 395-4115
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