The chemistry program at Caltech provides depth in the traditional areas of chemistry—organic and inorganic chemistry, chemical physics, theoretical chemistry, and chemical biology. Research areas include chemical synthesis and catalysis, chemical dynamics and reaction mechanisms, biochemistry, bioinorganic, bioorganic, and biophysical chemistry, and materials chemistry.

Chemical research at Caltech is also highly interdisciplinary, mirroring the increasing importance of molecular understanding in many fields of science. Major initiatives are fostering broad collaborations in energy and environment, molecular medicine, and nanomaterials.