Wednesday, March 7, 2018
4:00 pm
Noyes 153 (J. Holmes Sturdivant Lecture Hall)

Organic Chemistry Seminar

Reaction Development in the Amide Playground
Naoya Kumagai, Ph.D., Chief Researcher, Division of Chemistry, Institute of Microbial Chemistry, Tokyo

I will deliver 4 topics on the amide functionality:

1. Direct enolization chemistry of amide via designed asymmetric cooperative catalytic system.  [JACS 2015, 137, 15929, etc.]
2. Utility of asymmetric amide-based ligand for asymmetric flow catalysis.  [ACIE 2013, 52, 6196, etc.]
3. Catalytic direct dehydrative amidation by a novel B3NO2 heterocyclic catalyst.  [Nature Chem. 2017, 9, 571 etc.]
4. Twisting amide planarity: structural study and reactivity.  [Chem. Sci. 2017, 8, 85, etc.]

These issues will be discussed with emphasis on synthetic utility and reaction mechanisms.

Contact Vicky Brennan at x6151
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