Wednesday, April 25, 2018
4:00 pm
Noyes 153 (J. Holmes Sturdivant Lecture Hall)

Organic Chemistry Seminar

Cross-Coupling Reactions Enabled by Oxidative Catalysis and Decarboxylation
Rylan Lundgren, Assistant Professor of Chemistry, Department of Chemistry, University of Alberta

Metal catalyzed oxidative cross-couplings between two different nucleophilic components can offer advantages over alternative forms of contemporary coupling reactions, particularly with regard to tolerance towards reactive electrophilic functional groups. However, efficient coupling without undesirable substrate oxidation or homo- coupling presents a persistent difficulty. Our group has developed copper-mediated oxidative arylation reactions using aryl boron reagents and weak CH acids capable of undergoing decarboxylation. This presentation will discuss key observations and experimental parameters that allowed for reaction development, mechanistic aspects of the process, and applications in bioactive molecule synthesis and functionalization.

Contact Annette Luymes at 626-395-6016
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