Postdoc Opportunities in CCE
For additional information please visit the Postdoctoral Scholars page
Post-doctoral fellowship position in genomic instability, DNA replication and Recombination in the Campbell Lab
Cancer cells are undergoing replication stress due to oncogene activation or ablation of tumor suppression. Recent studies point to stalled replication forks as major culprit in generating mutation and genome rearrangement that correlate with tumor progression. The aim of our studies is to understand events at stalled DNA replication forks. Projects range from delineation of the delicate balance of remodeling, degradation and restart at stalled replication forks involving helicases and nucleases to characterization of small molecule inhibitors of one of the major players in replication fork stability. These inhibitors have applications in killing replication stressed tumor cells, in sensitizing tumor cells to chemotherapies and radiation therapies that interfere with replication fork progression, and synergizing with other DNA repair inhibitors in combinatorial therapies. A background in the DNA damage response, repair, recombination, and/or DNA replication is preferred but not essential.
Candidates with a record of publication in peer–reviewed journals and expertise in human cell culture, shRNA and siRNA knockdowns, IPs, westerns, cell line derivation, standard molecular biological techniques and cell biological techniques (e.g. immunfluorescence, cell cycle, and chromosome analysis) are sought. Experience with pulse-labeling of DNA, DNA fiber tracking, protein expression and/or purification, in vitro assays of enzymes of DNA metabolism, mouse xenograft experiments, and/or bioinformatics is preferred but not required.
To apply: Please send a detailed curriculum vitae, a short statement on future research goals, and names and contact details for three references, including your PhD supervisor, to Prof. Campbell at email@example.com
Two Postdoctoral Scholar Positions in the Ondrus Lab
The Ondrus lab is seeking postdoctoral scholars to investigate specific aspects of metabolic control within the Hedgehog signaling pathway. We employ a unique, interdisciplinary combination of small molecule synthesis, protein biochemistry, and genetic screens to elucidate mechanisms of endogenous metabolite signaling. Our ultimate goal is to define actionable metabolic regulators as therapeutic targets for Hedgehog pathway-driven congenital diseases and cancers. For more information, please see our website at http://www.ondruslab.caltech.edu
Applicants should send a one-page cover letter describing their specific interests and capabilities for the proposed work, as well as their future career plans. Applications must also include a CV, a description of past work (one page maximum), and three contacts for letters of reference. All materials can be sent directly to Prof. Ondrus at firstname.lastname@example.org.
Postdoctoral Scholar Position in Genetic Screening
We are seeking individuals to conduct pooled CRISPR/Cas9 screens targeting metabolic pathways involved in Hedgehog signaling. This is a unique opportunity to use high-throughput screening to investigate metabolic regulation. Applicants must have a PhD in cell, molecular, or systems biology, an established publication record, and strong leadership capabilities.
We welcome applicants in the following areas:
· Individuals with extensive experience in mammalian cell culture involving CRISPR/Cas9, including basic cloning techniques, lentivirus production, guide validation and optimization, DNA isolation, and next generation sequencing. Experience with flow cytometry is beneficial but not required.
· Individuals with expertise in computational/systems biology to participate in guide design and data analysis, including next-generation sequencing strategies, statistical evaluation of results, and generation of genetic interaction maps. Programming ability in Java, Python, and/or MATLAB/R is required.
Postdoctoral Scholar Position in Protein Engineering
We are seeking individuals with a background in structural biology to study posttranslational modifications of Hedgehog pathway proteins. This position involves investigating novel aspects of protein biochemistry and developing tools to study Hh pathway morphogenesis. Available research areas include protein structural characterization, high throughput mutagenesis screens, molecular dynamics simulations, and development of chemical genetic tools to study morphogen gradients in vivo. Applicants must have a PhD in biochemistry or structural biology, an established publication record, and the ability to work both independently and collaboratively. Extensive familiarity with techniques in molecular biology and in vitro protein expression is required, along with experience in x-ray crystallography, cryo-electron microscopy, or NMR analysis.
Postdoctoral Scholars in Aerosol Science
RESEARCH OPPORTUNITIES FOR POSTDOCTORAL SCHOLARS
The Division of Chemistry and Chemical Engineering at the California Institute of Technology invites applications for Postdoctoral Scholar appointments in the various fields of interest to the Division. In chemistry, new postdoctoral scholars may be appointed in the fields of biochemistry, chemical physics, organic chemistry, inorganic chemistry, theoretical chemistry, electrochemistry, and structural chemistry. Research opportunities in chemical engineering include atmospheric chemistry, chemical reaction engineering, bioengineering, fluid mechanics and transport phenomena, catalysis, surface chemistry, and polymeric materials.
Caltech is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, disability status, protected veteran status, or any other characteristic protected by law.