Postdoc Opportunities in CCE
For additional information please visit the Postdoctoral Scholars page
Postdoctoral Position in the Goddard Lab
Prof. William A. Goddard III at Caltech (Pasadena CA) is seeking for an exceptional postdoctoral scholar to join our team to work in the area of protein modeling and drug discovery using molecular dynamics (MD) simulations. The project mainly involves predicting and modeling structures of G protein-coupled receptors (GPCR), prediction of binding free energies of various ligands acting on the GPCRs, and finding the activation pathway for the GPCR to activate the G-Protein (GP). The project is centered on taste receptors where it is expected that many factors in addition to activation of the GP by the GPCR may play important roles in taste perception (competition with other ligands, role of allosteric modulators, transport into the cell and to the GPCR). Thus to understand dose-response an important component will be to use chemometrics involving descriptors for the ligand and other aspects of the cells to supplement binding and activation barriers from the MD.
This position is now available to be filled.
Qualified candidates must hold a Ph.D. in Chemistry, Physics, Biological Science, Materials Science, Chemical Engineering, or a related area, with a strong track record of productivity. Candidates are expected to have demonstrated capabilities in several of the following areas:
- Experience with protein-ligand docking and in homology predictions of membrane bound proteins
- Classical molecular dynamics (MD) simulations with a variety of force fields.
- Proficiency in using well-established MD software package such as GROMACS and NAMD.
- Expertise in enhanced sampling methods and free energy calculations.
- Experience with chemometrics
- Strong skills in biological sequence analysis, building proteins, homology modeling, or other protein structure prediction techniques.
- Proficient in scripting languages such as Python and Perl
- Excellent communication in spoken and written English.
And they should be resourceful and unafraid to tackle impossible problems.
Qualified applicants should send:
- CV with contact information and list of publications
- Visa status if not a US citizen
- Three personal references familiar with your background and accomplishments. Include phone numbers, fax numbers, and e-mail addresses, so we can contact them.
- One paragraph description of how your background is appropriate for our projects
- Two paragraph description of your career goals and how this position would be consistent with your goals.
- Pdf for your best 3 publications
Put as the subject title: Application for GPCR PD with Goddard, your name, your institution
Salary is commensurate with demonstrated capabilities and experience. Caltech offers an attractive benefits package and a comfortable living environment in the San Gabriel Valley near Los Angeles. Caltech is an equal opportunity employer.
Postdoctoral Position in Synthetic Organic Chemistry - Chemical Biology
The Ondrus Lab employs a cross-disciplinary approach to elucidate the signaling functions of metabolites in human health. Specifically, we are addressing long-standing questions about the roles of cholesterol metabolites in development and disease via the Hedgehog signaling pathway. For more details about our lab, please see our website at www.ondruslab.caltech.edu.
We are seeking postdoctoral candidates with a proven track record of excellence in synthetic organic chemistry to synthesize sterol-based probes and characterize their activities using cutting-edge techniques in proteomics. The successful applicant will assume a leadership role in developing new technology at the chemistry-biology interface. Applicants must have least one first-author publication on complex molecule synthesis in a peer-reviewed journal and expertise in synthetic techniques (2D NMR, HPLC, LC/GC-MS, IR, etc.). Experience with cell biology (cell culture, reporter assays, Western Blotting, etc.) and proteomics analysis is an advantage. As a senior lab member, the successful applicant will also oversee and participate in lab operations, establish project-based collaborations within and outside of Caltech, provide mentorship to junior colleagues, and actively seek external funding.
For consideration, applicants may reply to this posting via the Science Careers website (https://jobs.sciencecareers.org/job/474097/postdoctoral-position-in-synthetic-organic-chemistry-chemical-biology/) or by email to firstname.lastname@example.org with the following required documents:
Postdoctoral fellowship position in genomic instability, DNA replication and Recombination in the Campbell Lab
Cancer cells are undergoing replication stress due to oncogene activation or ablation of tumor suppression. Recent studies point to stalled replication forks as major culprit in generating mutation and genome rearrangement that correlate with tumor progression. The aim of our studies is to understand events at stalled DNA replication forks. Projects range from delineation of the delicate balance of remodeling, degradation and restart at stalled replication forks involving helicases and nucleases to characterization of small molecule inhibitors of one of the major players in replication fork stability. These inhibitors have applications in killing replication stressed tumor cells, in sensitizing tumor cells to chemotherapies and radiation therapies that interfere with replication fork progression, and synergizing with other DNA repair inhibitors in combinatorial therapies. A background in the DNA damage response, repair, recombination, and/or DNA replication is preferred but not essential.
Candidates with a record of publication in peer–reviewed journals and expertise in human cell culture, shRNA and siRNA knockdowns, IPs, westerns, cell line derivation, standard molecular biological techniques and cell biological techniques (e.g. immunfluorescence, cell cycle, and chromosome analysis) are sought. Experience with pulse-labeling of DNA, DNA fiber tracking, protein expression and/or purification, in vitro assays of enzymes of DNA metabolism, mouse xenograft experiments, and/or bioinformatics is preferred but not required.
To apply: Please send a detailed curriculum vitae, a short statement on future research goals, and names and contact details for three references, including your PhD supervisor, to Prof. Campbell at email@example.com
Postdoctoral Scholars in Aerosol Science
RESEARCH OPPORTUNITIES FOR POSTDOCTORAL SCHOLARS
The Division of Chemistry and Chemical Engineering at the California Institute of Technology invites applications for Postdoctoral Scholar appointments in the various fields of interest to the Division. In chemistry, new postdoctoral scholars may be appointed in the fields of biochemistry, chemical physics, organic chemistry, inorganic chemistry, theoretical chemistry, electrochemistry, and structural chemistry. Research opportunities in chemical engineering include atmospheric chemistry, chemical reaction engineering, bioengineering, fluid mechanics and transport phenomena, catalysis, surface chemistry, and polymeric materials.
Caltech is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, disability status, protected veteran status, or any other characteristic protected by law.