Wednesday, April 18, 2018
2:00 pm
Crellin 151

Special Chemical Engineering Seminar

Olfactory receptor-based sensors to accelerate the engineering of chemical-producing microbes
Pamela Peralta-Yahya, Assistant Professor, School of Chemistry and Biochemistry, Georgia Institute of Technology

One of the major challenges in the engineering of microbes for the production of chemicals is the rapid identification of the highest chemical-producing microbe from a pool, akin to finding a needle in a haystack. Chromatography-based methods for the strain-screening step limit the screening throughput to ∼100 chemical-producing microbes per day. Biosensors that link chemical detection to fluorescence have the potential to enable the screening of more than a million chemical-producing microbes per day. Here, I will present work on the rapid engineering of olfactory receptor-based sensors to detect different chemicals from advanced biofuels and pharmaceutical-like compounds. We are using these sensors for the high-throughput screening of chemical producing microbes, and considering how this throughput now allow us to apply evolutionary approaches to the bioproduction of non-colorimetric chemicals.

Contact Sohee Lee sohee@cheme.caltech.edu at 626-395-4193
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