Macromolecular Function: kinetics, energetics, and mechanisms
9 units (3-0-6) |
Prerequisites: Ch/Bi 110 or equivalent.
Discussion of the energetic principles and molecular mechanisms that underlie enzyme's catalytic proficiency and exquisite specificity. Principles of allostery, selectivity, and enzyme evolution. Practical kinetics sections discuss how to infer molecular mechanisms from rate/equilibrium measurements and their application to more complex biological systems, including steady-state and pre-steadystate kinetics, kinetic simulations, and kinetics at single molecule resolution.
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