Chemical Engineering Seminar
Recent technological advances in genomics and proteomics have driven an explosion in our knowledge of the molecular parts within cells. Interactions between these parts drive all biological processes: proteins bind DNA and RNA to regulate transcription and translation,
dense networks of protein-protein interactions convey cellular signals, and enzyme-substrate interactions allow all of the chemical transformations essential for metabolism and signaling. The strength of these interactions predicts the timing and identity of downstream responses; therefore, quantitative biophysical and biochemical measurements are critical to decipher these networks, predict how they are disrupted in disease, and manipulate them for therapeutic
purposes. In this seminar, I'll present the development of and results from several new microfluidic platforms that make it possible to acquire quantitative biochemical and biophysical data in vitro for thousands to millions of sequence variants in parallel.